Follicular lymphoma (follicular lymphoma) Follicular lymphoma is an indolent B-cell tumor derived from cells in the germinal center of lymphoid follicles. It accounts for about 25% to 45% of the NHL in European and American countries or regions

Non-Hodgkin's lymphoma (NHL) accounts for about 80% to 90% of all lymphomas, of which two-thirds are primary in the lymph nodes, and one-third are primary in organs or tissues outside the lymph nodes, such as Digestive and respiratory tract, lungs, skin, salivary glands, thyroid and central nervous system, etc.

Non-Hodgkin's Lymphoma (NHL) is a general term for a group of independent diseases with strong heterogeneity. NHL lesions are malignant tumors that mainly occur in lymph nodes, spleen, thymus and other lymphoid organs, and can also occur in lymphoid tissues and organs outside the lymph nodes. According to the source of cells, they are divided into three basic types: B cells, T cells and NK/T cells NHL

Pre-B-cell ALL/LBL patients are mainly children under 10 years of age, with extensive bone marrow involvement, swelling of the liver, spleen, and lymph nodes, as well as abnormal cells in the peripheral blood. Patients with pre-T-cell ALL are mostly adolescents

The tumor cells of Burkitt's lymphoma are relatively mature B cells, which express monoclonal cell membrane surface immunoglobulins such as sIg, CD19, CD20 and CD10. All Burkitt lymphomas have translocations related to the c-myc gene on chromosome 8. The most common is t(8;14), and t(2;8) or t(8;22) can also occur.

Since NHL is a general term for a group of malignant tumors of the lymphoid hematopoietic system, the clinical manifestations have certain common characteristics, and at the same time, there are great differences according to different pathological types, sites and extents of the invasion. Although the disease occurs in the lymph nodes, according to the distribution characteristics of the lymphatic system, NHL is basically a systemic disease.

NHL examinations can be divided into traumatic and non-traumatic examinations. Traumatic examinations are mostly carried out by taking histological specimens for diagnosis, while non-invasive examinations are mostly carried out for finding the location of the lesion, evaluating the extent of the lesion and evaluating the therapeutic effect.